The twelve regular meridians, connected with each other by the divergent meridians and divergent collaterals, form six pairs of exterior-interior relationships. Their exterior-interior relationships are as follows: the Large Intestine Meridian of Hand-Yang-ming and the Lung Meridian of Hand-Taiyin; the Tri-eneryizer Meridian of Hand -Shaoyang and the Pericardium Meridian of Hand-Jueyin; the Small intestine Meridian of Hand-Taiyang and the Heart Meridian of Hand-Shaoyin; the Stomach Meridian of Foot-Yang ming and the spleen Meridian of Foot-taiyin; the Gallbladder Meridian of foot-Shaoyang and the Liver Meridian of Foot-Jueyin; and the Urinary Bladder Meridian of Foot-Taiyang and the Kidney meridian of Foot-Shaoyin. The Taiyang meridian and Shaoyin meridian of foot are exteriorly-interiorly related, and so are the Shaoyang meridian and the Jueyin meridian of foot, and the Yangming meridian and Taiyin meridian of foot. These are called the  yin and yang of foot"; while the Taiyang meridian and the Shaoyang meridian of hand are exteriorly-interiorly related, and so are the Shaoyang and the Jueyin meridians, and the Yangming and the Taiyin meridians of hand.These are called the "yin and yang of hand".

The exterior-interior relationship of the twelve meridians not only strengthen the connection between each specific pair of meridians with exterior-interior relationship, but also promote each pair of zang -fu with the exterior-interior relationship to coordinate cach other physiologically and influence each other pathologically. In treatment, acupoints of the two meridians with the exterior-interior relationship may be alternatively used.

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